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David M. Luesley MA MD FRCOG

  • Lawson Tait Professor of Gynaecological Oncology, School
  • of Cancer Sciences, University of Birmingham
  • and Clinical
  • Director, Pan-Birmingham Gynaecological Cancer Centre, City
  • Hospital, Birmingham

Projects can be started together with local villagers to make essential species more available through small-scale cultivation which also lessen the risk for species extinction account for hiv infection cycle order medex with visa. In the end the value of traditional plant knowledge antiviral paint buy medex in united states online, generally acquired over hundreds of years quantum antiviral formula buy medex with paypal, and the value of plant species themselves cannot be over emphasized (Farnsworth & Soejarto 1985) hiv infection pathogenesis purchase genuine medex on line. Laos with its rich flora and high ethnic diversity create unique possibilities for further ethnobotanical research antiviral rx trusted medex 5mg. Much remains to be learned about the essential use of traditional medicine during pregnancy xl3 accion antiviral purchase medex with american express, birth and convalescence as well as the similarities and differences regarding plant use between the ethnic groups. Further phytochemical, pharmacological and clinical studies could improve the knowledge about beneficial and potentially harmful plant remedies and allow for incorporation of some of these remedies in an organized system of health care. Furthermore knowledge of the active substances would facilitate standardization and defined dosages. I appreciate all inventive ideas, feedback on previous versions of the report and help with the onerous identification of specimens. I wish to thank my co-student Lina Ahnby for all her work put into the study, her positive attitude and talent for making things possible, Amsy Ounmany and Fongsamude Sivilay who interpreted and helped with the plant collections during the fieldwork, Paphavadee Keomaungsan who kindly provided plant material for distillation and shared her expertise about steam saunas, Say Phonekeo and Chantala Saphakdy for their hospitality and friendly support throughout the study. Thank you for sharing time and knowledge regarding births, plants and plant remedies. I thank also the Swedish International Development Cooperation Agency (Sida) for financial support. Antinociceptive activity of the aqueous extract of Zizyphus spina-christi root bark extracts. Plants and people of the Golden Triangle, Ethnobotany of the hill tribes of northern Thailand. The structure and stereochemistry of phlogantholide-A, a diterpene from Phlogacanthus thyrsiflorus. An extract of Curcuma longa exerts anti-oxidative, anti inflammatory and antiproliferative effects on human keratinocytes in vitro. Testing of lipoxygenase inhibitors, cycloxigenase inhibitors, drugs with immunomodulating properties and some reference antipsoriatic drugs in the modified mouse tail test, an animal model of psoriasis. Paper presented at International symposium on alternative approaches to enhancing small-scale livelihoods and natural resources management in Marginal Areas. Safety and anti-inflammatory activity of curcumin: a component of Tumeric (Curcuma longa). In: Landscapes of Diversity: Indigenous Knowledge, Sustainable Livelihoods and Resource Governance in Montane Mainland Southeast Asia. Potential consequence of plant extinction in the united states on the current and future availability of prescription drugs. Superoxide radical scavenging properties of extracts and flavonoids isolated from the leaves of Blumea balsamifera. Beliefs and practices regarding delivery and postpartum maternal morbidity in rural Bangladesh. Drug-induced suppression of phosphorylase kinase activity correlates with resolution of psoriasis as assessed by clinical, histological and immunohistochemical parameters. Folk herbal medicines used in birth control and sexual diseases by tribals of southern Rajasthan, India. Anti-inflammatory effects of eucalyptol (1, 8-cineole) in bronchial asthma: inhibition of arachidonic acid metabolism in human blood monocytes ex vivo. Activity of triterpenoid glycosides from the root bark of Mussaenda macrophylla against two oral pathogens. Health consequences of pregnancy and childbirth as perceived by women and clinicians. Blood levels of 1, 8 cineol and locomotor activity of mice after inhalation and oral administration of rosemary oil. Cardiovascular effects of 1, 8-cineole, a terpenoid oxide present in many plant essential oils, in normotensive rats. Antiviral activities of medicinal herbs traditionally used in southern mainland China. Isolation and structure determination of cassumunarins A, B, and C: new anti-inflammatory antioxidants from a tropical ginger, Zingiber cassumunar. Prostaglandin Synthesis Inhibitory Activity in Zulu, Xhosa and Sotho Medicinal Plants. Chemical composition of the volatile oil from the pericarp (husk) of large cardamom (Amomum subulatum Roxb. Analgesic and anticonvulsant effects of extracts form the leaves of Kalanchoe crenata (Andrews) Haworth (Crassulaceae). Study on the chemical composition of essential oil extracted from leaves of Blumea balsamifera (L. Life-threatening primary postpartum hemorrhage: treatment with emergency selective arterial embolization. Assessing cultural and ecological variation in ethnobiological research: the importance of gender. Dietary compounds inhibit proliferation and contraction of keloid and hypertrophic scar-derived fibroblasts in vitro: therapeutic implication for excessive scarring. Maternal and infant health problems after normal childbirth: a randomised controlled study in Zambia. Antiinflammatory and antinociceptive effects of 1, 8-cineole a terpenoid oxide present in many plant essential oils. Coming to the cultural "in-between": nursing insights from a Hmong birth case study. Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti inflammatory agent. Introduction to Swedish by Urban Sikeborg, Stockholm (1997-1998), Handelshogskolan I Stockholm, Sweden. Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay. Postpartum hemorrhage in developing countries: is the public health community using the right tools Ambulation-promoting effect of peppermint oil and identification of its active constituents. Effect of Mimosa pudica root powder on oestrous cycle and ovulation in cycling female albino rat, Rattus norvegicus. Anti-tumour promoter activity in Malaysian ginger rhizobia used in traditional medicine. Managing complications in pregnancy and childbirth: a guide for midwives and doctors. Phytoconstituents of Phlogacanthus tubiflorus Nees (Acanthaceae): Phlogacanthin, a new diterpene lactone (andrographolide) isolated from the root wood. Isolation of a new diterpene lactone glucoside from Phlogacanthus guttatus Nees (Acanthaceae). U sedonceaday Skindisease, norm ally during 5-6daysif plantm aterialisavailable occurring betweenfingers, in groinsandarm pits Aglaonemasp. The extractisdrunkeverym orning beforebreakfast untilfeeling better Ajugamacrospermavar. K hao workandtiredness, orif to Decoctionfrom choppedrootisdrunkhot skinny Alpiniacf. Stem and Decoctionforsteam bath3tim esperdayduring 10 (Alsousedinfood, taking leaves dayspostpartum. U sedincom binationwith:Gok awaybadsm ellonfishand paiven, Puakm aipuay, andPuakm aikadan m eat) Alpiniasp. K hao workandtiredness, orif to Decoctionfrom choppedrootisdrunkhot skinny Alpiniasp. Canbeused recoveryof strength/health incom binationwith(Gok)M akneng kam, Gok pidinandGokpai-ven Alpiniasp. Canbeusedincom bination 2:F ood 2:Shoot withM akneng noiandGokpai-ven androot 2:Young shootsarecookedandeatenunderrainy seasonandrootsareusedinchillim ix, soup, la:p Amomum cf. K hao causedbyhardwork leaf Crushedleavesareappliedontheplaceof pain during 2-3days, changed3tim esaday Amomum cf. F reshordriedshoots, K hao leaf or leavesorrootareboiledtogetherwithAjeneand root drunkastea Amomum cf. Crushedplantm aterialisappliedonthe bywork, accidentor placeof painandchangedtwotim esperdayuntil rheum atism thepaindisappear Amomum cf. Canbeused andPeo F euang 2:Sold leaf togetherwithK a 2:F ruitsaresoldtoLaoandV ietnam ese Amomum sp. Stops Leaf Appliedonthewound Soyae K hao haem orrhage Artocarpusheterophylla M O R M a:m i w Laser Lao Lactagoge Leaf and Decoctiondrunkinsteadof wateruntilm ilkis K hao fruit com ing Artocarpusheterophylla M O R M a:m i(Jakfruit) 50 c Yehaand Lao Prom otelactation Young E atenatleast3tim es/dayuntilenoughm ilkis Soyae K hao leaf and produced bud Asparagussp. Breastm assagedwithsingedyoung leaves(m assage canbeperform edonitsownaswell) Beilschmiediacf. U sed Skindisease, norm ally onceadayduring 5-6daysif plantm aterialis occurring betweenfingers, in available. Drunkinsteadof (Jakepoa, lao K hao abletoeatfood plant wateruntilfeeling better nam e) Clerodendrum fragrans V E R Hahondetze 86 w Yeha Lao Stop postpartum haem orrhage Leaf Placedonthechairorbedtositorlieon K hao andprom otehealing (of postpartum. Preferablyusedincom binationwith uterus) SutziandO sam a Clerodendrum fragrans V E R N jong-m e 118 w Laolee N am Lactagogeandprom ote R oot Decoctionism adeincom binationwithLo-gajand Lue postpartum recoveryof M ainjeng dong. O nehandof cleanedandchopped strength plantm aterialisboiledfor10-20m inanddrunk insteadof waterduring oneweekoruntilenough m ilkareproducedforthebaby Coscinium fenestratum M E N K uaha:m 9 w K ham phon K aoy Sold Stem, Pickandsoldatthem arket bark Coscinium fenestratum M E N K uaha:m 9 w Long M aet M ak M alaria, preventiveorcure Stem Singed, cleanedandusedfordecoction. Decoction Laonam e) K hao lowerpart from choppedplantm aterialisdrunkinsteadof of stem wateruntilyoufeelbetter Crotalariaassamicavar. Crushedplantsareappliedontheplace bywork, accidentor of painandchangedtwotim esperdayuntilthe rheum atism paindisappear Curcumasp. Decoctionm ixedwith K hao parts coldwaterandusedforbathing thebabyone tim e/dayduring oneweek. Decoctiondrunk kang (Takong andK haet F euang haem orrhage asteauntilthebleeding stops. M E N V om khatm a 177 w Laolee N am Heartburn Leaf Leavescleanedandcrushedwithwaterturnsintoa Lue jellythatareeatenwithaddedspring onion, saltand seasoning powder. Drinkasm uchaspossibleuntil andweightloss feeling stronger, sam eplantm aterialcanbeusedfor 3pots Ficussp. M O R Spo 64 w Yehaand Lao Antipyretic Young U sedtogetherwith"M itjalajaga"andTjim epapu. Soyae K hao stem and Decoctionm ixedwithcoldwatertowashyourself leaf Fissistigmasp. E U P K atap dom 167 w Laolee N am Stom achache, diarrhoea R ootor Young leaveseatenorrootboiledfor10m inand Lue young leaf thedecoctiondrunkinsteadof wateruntilfeeling better Gonocaryum sp. Perform once Skindisease, norm ally adayduring 5-6daysif plantm aterialisavailable. K hao causedbyhardwork Crushedleavesareappliedontheplaceof pain during 2-3days, changed3tim esaday Mallotusbarbatus E U P K ratnom, 111 w Laolee N am Preventflylarvaeinfectionof Leaf Crushedleavesandputonthewound (K ohTao Lue anim alwoundsandcuts hoang, Baihoa sang Laonam e) Mallotusbarbatus E U P M aihoasa:ng 23 w Long M aet M ak Diarrhoea R oot/ 3potsof decoctiondrunk. Stem /rootsingedand andPeo F euang Stem barkrem ovedbeforeuse Mallotusbarbatus E U P M aihoasa:ng 23 w ChanHom M ak Diarrhoea R oot Decoctiondrunk, m adeof signedroot (K atorra:tjian) andK haet F euang Melastomacf. O ver tohavem orechildren dosagecandam agehealthandcauseperm anent infertility Melastomasp. M E L Tam chan(Gok 119 w Laolee N am Diarrhoea Root Decoctiondrunkinsteadof waterthreetim esaday. R U B Pabaobai 126 w K aotho N am Headacheordizziness Leaf Cleaned, crushedleavesareputonforeheadfor2 V ang orR oot 3h. W hensuffering from strong headachecleaned andchoppedrootareboiledfor10m inanddrunk 3tim esaday. Againstpainthedriedsap from thefruitare Pain sm okedandsom etim esm ixedwithcrushed paracetam ol Peliosanthessp. Leaves annamensis Soyae K hao andprom otehealing inside changedwhendry Phlogacanthuscf. K hao andtierdness, orif toskinny Decoctionfrom choppedrootisdrunkhot Phyllanthuscf. N otcaused Crushedleavesareappliedontheplaceof painand bywork, accidentor changedtwotim esperdayuntilthepaindisappear rheum atism Rhaphidophoracf. Crushedplantsareappliedontheplace bywork, accidentor of painandchangedtwotim esperdayuntilthe rheum atism paindisappear Rhuacophilacf. O nehandof cleanedand strength choppedplantm aterialisboiledfor10-20m inand drunkinsteadof waterduring oneweekoruntil enoughm ilkareproducedforthebaby Selaginellasp. Asm uchas andPeo F euang yellowing of skinandeyes, and (bark possibleuntilfeeling better weakness(nofever) rem oved) Tetrastigmasp. A K hao 15 leaf bunchof plantsisplacedonthechildandam agic spelling isperform ed Zingibercf. Canbeused andK haet F euang 2:Sold andleaf togetherwithK aandGokpaiven 2:F ruit 2:F ruitsaresold Zingibersp. K objanajaga 79 w Yeha Lao Sorethroat W hole Decoctionm adetogetherwithHatjekuta, 2L of K hao plant waterto1handof cutplantm aterial. U sedoncea Skindisease, norm ally dayduring 5-6daysif plantm aterialisavailable occurring betweenfingers, in groinsandarm pits Indet. A bunchof K hao leaf plantsisplacedonthechildandam agicspelling is perform ed Indet. Jasam agu 62 w Laser Lao Coughing blood R oot Decoctionm adefrom cutrootdrunk3tim esaday K hao untilbetter. Jatjitha 41 w Laser Lao Afteraccident, swelling and Bark Infusionm adefrom cutbark.

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Before starting the interview hiv infection oral route buy 1 mg medex mastercard, they were asked for consent for audio recording of the whole interview antivirus windows 8 purchase medex online now. Each interview was continued with an introduction and collection of information on demographic characteristics (age hiv infection long term effects order 1mg medex, marital status hiv infection needle stick cheap medex online mastercard, employment hiv infection among youth 1mg medex otc, literacy) and completed in approximately 60 minutes hiv infection graph discount medex line. After finishing each interview, both the moderator and note taker reviewed the notes taken and consolidated them to be incorporated in the interview text when the audio file was transcribed. All names were coded in the interviews and finally transcribed data was used for detailed analysis. Then researchers coded all interviews and then classified all codes under specified subthemes and themes. Inductive content analysis was applied to code all interviews based on developed nodes by free coding. By analyzing them we noticed redundancy in coding and no new node or theme arose which indicated data saturation. Results Characteristics of the sample Table 3 shows a summary of the demographic characteristics of interview participants. No illiteracy was reported and five out of 81 respondents (6%) reported having completed university education. Knowledge about cervical cancer and cervical cancer screening 9 Characteristics Frequency Percentage (%) Age Mean=39. Tacit knowledge is embedded in practical experiences, not achieved through systematic or formal trainings, and not from standard documents, and it is nonspecific. By contrast, explicit knowledge is evidence-based, specific and precise knowledge which could be articulated and communicated systematically (50). The results revealed different subthemes for this area, which are discussed below. Lack of explicit knowledge on cervical cancer Most of the women had heard about cervical cancer in general, but had not specifically mentioned the exact name of cervical cancer in the discussion. According to participants, older women have less knowledge than the younger generation. The majority of interviewees were also unable to differentiate between cervical cancer and other genital cancers. Several women stated hemorrhage (vaginal bleeding) and vaginal discharge (extensive and smelly) as hallmark symptoms. One of our relatives was affected and within six months, when in hospital, her uterus was removed but it was rooted in her abdomen I guess the first symptom is severe bleeding. Occasionally interviewees mentioned other signs such as abdominal pain, genital burning and irritation. Lack of specific knowledge on testing purpose, frequency and timing 11 the majority of women knew about cervical cancer testing but their knowledge in most of the cases was nonspecific and inaccurate concerning the purpose and frequency (timing) of testing. The cervical cancer screening test was referred to by different names: Pap smear, cancer testing, women testing. It was very frequently stated that this test (Pap smear testing) diagnoses sexually transmitted infections and cancer (not specifically cervical cancer). Almost all women who had previously taken the test stated that the first time they had undergone testing was when they visited their health care provider (physician, gynecologist or midwife) for reproductive health reasons after marriage, during pregnancy or after giving birth. They expressed broad knowledge about timing and frequency of testing, including twice a year, annually, every three years, etc. When we have passed reproductive age and after aging, it (testing) also needs to be done, and likewise after surgery (hysterectomy) which I had, after extraction of my uterus. In addition, interviewees mentioned different ages and circumstances as starting time for testing, including after marriage, before pregnancy, after giving birth (delivery), after turning 30 years old, from age 20 to 60 years, and after the menopause. Several women indicated that women should be 12 examined and tested for disease (i. The majority of interviewed women explained the testing as taking samples on slides and a few of them talked about taking samples in liquid mediums. A few participants noted that there are several ways to diagnose cervical cancer, and mentioned biopsy and diagnostic curettage as additional options. If the result of the test is suspicious then the test should be repeated and in the case of an infection, it is cured with pills and medicine. In addition, they listed other risk factors, including multiple partnerships, ignoring personal hygiene (cleaning and washing the genital organs, daily changing of underwear), unhealthy nutrition. Only two participants mentioned smoking tobacco and alcohol use as possible risk factors. Almost none of the women differentiated between cleanliness and hygiene in their statements and expressed an implicit understanding of hygiene to control risks. We should be concerned about our sexual relations a lot, also about our underwear which I think is highly important. They stated practical terms and conditions for testing including sexual abstinence, avoiding the use of vaginal douche and vaginal treatments (gel and cream), and recommended scheduling testing when not the menstruating. Additionally, sexual intercourse should not have taken place in the previous 24 hours (before testing) and (vaginal) ointments should not be used during the previous 48 hours. Limited and unspecified knowledge on preventive measures, care and treatment Almost all women indicated not knowing how to prevent cervical cancer; they indicated that they were simply advised to perform the test. Only two women mentioned the availability of a vaccine and its preventive role; both women were highly educated. The majority of women considered cervical cancer as a treatable disease if diagnosed early, by extraction of the uterus and chemo or radiotherapy, before metastasis to other organs. There was an overall low perceived susceptibility and high perceived severity among participants regarding cervical cancer. Overestimation of the role of heredity of cervical cancer was an important misconception among women; most women considered themselves not at risk because there was no (known) history of cervical cancer in their family. A common social belief in Iran says that when you think of something it eventually happens to you, and this scares people away from exploring their concerns like cancer. Aggravated severity due to social and cultural misperceptions Most women reported a high perceived severity of cervical cancer; severe consequences also included disruption of family life and social image. Most women indicated that talking about issues related to the sexual organs including cervical cancer and testing is stigmatized according to cultural and social norms. Usually she keeps it secret, like breast cancer; she does not like others to know about her disease. They were concerned that senior professionals spend less time with patients for health education. Many women indicated that Iranian women prioritize family and household as a social value and criticize caring about personal health. Findings were summarized under three main themes including knowledge, perceived risk and perceived cues to act. Firstly, with regard to knowledge, our results revealed that a vast majority of women had general knowledge about cervical cancer and screening but their information was implicit rather than explicit. They did not differentiate between cervical cancer and other genitourinary cancers, mainly uterine cancer. Most of the women did not explicitly name cervical cancer and they did not anatomically distinguish the cervix from the uterus. Lack of knowledge and unconfident answers by women regarding timing, frequency and procedures was also reported in other studies (33, 52). It shows a shortfall in the health system lacking systematic health education and uniform practices (51). Consequently, receiving a cue to act as a result of discussions with others is rare in Iran. However, our findings did not indicate a constant pattern and do not suggest differences in awareness, knowledge and risk perceptions between participants with different socio-economic backgrounds. Moderating interviews by two experts of both genders and the openness shown by interviewees were other positive points of this study. The results of this study provide a wide range of comprehensive data on the above-mentioned thematic areas and advocate the development of health communication interventions to promote adequate uptake of cervical cancer testing in Iran. Although there is now a vaccine against cervical cancer, this is not yet available in Iran. In addition, women reported a low level of perceived susceptibility along with misconceptions influencing their uptake of preventive measures. Funding this research was funded by the Tehran University of Medical Sciences, Tehran, Iran (Project number: 92-04-51-24890). The funder of this project had no role in the development and design of the study; in the data collection and analyses, interpretation of results; in the development of the manuscript, or in the process of publishing the results. They prepared the initial draft and finalized it based on internal reviews and discussions among authors. All authors reviewed each manuscript draft, participated in interpreting the results, and approved the final version. Acknowledgments the Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran, supported this study. World Health Organization; Cancer prevention-Diagnosis and screening-Cervical cancer;. American Cancer Society; Cervical Cancer Prevention And Early Detection;. International Agency for Research on Cancer; Estimated number of new cases in 2018, Iran, Islamic Republic of; gco. Epidemiology of cervical cancer and human papilloma virus infection among Iranian women analyses of national data and systematic review of the literature. Loos, 1 Peter McCarron, 3 Elizabete Weiderpass, 1, 4, 5, 6 Mark Arbyn, 7, Henrik Moller, 8 Matti Hakama, 1, 9 and D. Trends in Cervical Squamous Cell Carcinoma Incidence in 13 European Countries: Changing Risk and the Effects of Screening. Patterns and trends in human papillomavirus-related diseases in Central and Eastern Europe and Central Asia. Socio 25 cultural challenges to sexual health education for female adolescents in Iran. World Health Organization; Draft: global strategy towards the elimination of cervical cancer as a public health problem; Accessed on 24 Jan 2020;available from. World Health organization;Global Health Observatory data repository, Cervical cancer screening Response by country; 2018; apps. Factors Related to Regular Undergoing Pap-smear Test: Application of Theory of Planned Behavior. World Health Organization;Islamic Republic of Iran on a fast-track to beating noncommunicable diseases; 2017;. Challenges of providing cervical cancer prevention programs in Iran: a qualitative study. Awareness and knowledge regarding of cervical cancer, Pap smear screening and human papillomavirus infection in Gabonese women. Personal and socio-cultural barriers to cervical cancer screening in Iran, patient and provider perceptions: a qualitative study. The Effect of Educational Program on Increasing Cervical Cancer Screening Behavior among Women in Hamadan, Iran: Applying Health Belief Model. Knowledge and attitude of Iranian University students toward human papilloma virus. Attitude and knowledge of Iranian female nurses about human papilomavirus infection and cervical cancer: a cross sectional survey. Knowledge and awareness of cervical cancer and screening among Malaysian women who have never had a Pap smear: a qualitative study. Reasons for non-attendance in cervical cancer screening programmes: an application of the Integrated Model for Behavioural Change. Factors Affecting Cervical Cancer Screening Behaviors Based On the Precaution Adoption Process Model: A Qualitative Study. Majidi A, Majidi S, Salimzadeh S, Khazaee Pool M, Sadjadi A, Salimzadeh H, et al. Cancer Screening Awareness and Practice in a Middle Income Country; A Systematic Review from Iran. An Integrated Approach for Understanding Health Behavior; the I-Change Model as an Example. Barriers to Cervical Cancer Screening Among Middle-Aged and Older Rural Appalachian Women. Barriers to cervical cancer screening faced by immigrant women in Canada: a systematic scoping review. Cervical Cancer Screening Among Arab Women in the United States: An Integrative Review. Application of four-dimension criteria to assess rigour of qualitative research in emergency medicine. A baseline study of communication networks related to evidence-based infection prevention practices in an intensive care unit. Knowledge and attitudes about human papillomavirus, Pap smears, and cervical cancer among young women in Brazil: implications for health education and prevention. Cervical Cancer Screening Experiences Among Chinese American Immigrant Women in the United States. Knowledge, attitudes, and demographic factors influencing cervical cancer screening behavior of Zimbabwean women.

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Treatment is recommended for infants with life or vision-threatening disease hiv infection rates state buy medex from india, such as severe retinitis hiv aids infection rate washington dc discount medex 5 mg overnight delivery, interstitial pneumonitis hiv infection symptoms prevention facts testing treatment purchase medex in india, hepatitis hiv transmission route statistics order medex 1mg amex, or thrombocytopenia hiv infection rate in zambia purchase medex canada. What is the risk to the fetus if the mother is infected with parvovirus B19 during pregnancy Theriskof fetalloss is2%to 10%andis greatestwhenmaternalinfection occursduringthefirst half of pregnancy hiv infection from topping buy discount medex 1mg online. Fetal loss occurs as a consequence of hydrops, which develops as a result of parvovirus-inducedanemia. An elevatedmaternal seruma-fetoprotein level maybe a marker for an adverse outcome. The signs of parvovirus infection in adults are not very distinctive but may include fever, a maculopapular or lacelike rash, and joint pain. What are the consequences of primary varicella infection during the first trimester The congenital varicella syndrome consists of a constellation of features: n Limb atrophy, usually associated with a cicatricial (scarring) lesion n Neurologic and sensory defects n Eye abnormalities (chorioretinitis, cataracts, microphthalmia, Horner syndrome) n Cortical atrophy and mental retardation this syndrome usually follows maternal infection during the first trimester, although it may be seen after infection up to 20 weeks into gestation. The largest prospective study reported to date found four cases of fetal varicella syndrome in 141 pregnancies, yielding an incidence of less than 3%. During this period of high risk, the fetus is exposed to high circulating titers of the virus without the benefit of maternal antibody synthesis. Ureaplasma urealyticum has been associated with low birthweight and bronchopulmonary dysplasia. This organism has been recovered from neonates with respiratory distress, pneumonia, and meningitis, but a causative role in these diseases has not been proved. Several reports of apparent Mycoplasma hominis meningitis and eye infection have been published. Risk for transmission is higher in preterm and low-birthweight infants and correlates with the prolonged rupture of membranes and maternal fever. Infants delivered by cesarean section over intact membranes have a very low rate of colonization compared with infants delivered vaginally. The most characteristic features of congenital rubella syndrome are congenital heart disease, cataracts, microphthalmia, corneal opacities, glaucoma, and radiolucent bone lesions. The features of congenital rubella syndrome can be divided into three broad categories: n Transient: Low birthweight, hepatosplenomegaly, thrombocytopenia, hepatitis, pneumonitis, and radiolucent bone lesions n Permanent: Deafness, cataracts, and congenital heart lesions (patent ductus arteriosus > pulmonary artery stenosis > aortic stenosis > ventricular septal defects) n Developmental: Psychomotor delay, behavioral disorders, and endocrine dysfunction 49. Existing data indicate that antepartum cultures of the maternal genital tract fail to predict viral shedding at the time of delivery. Only 3% to 5% of infants born to mothers with active recurrent disease become infected. Distinguishing between primary and recurrent herpes infections by history and clinical examination is often difficult. If membranes have been ruptured for longer periods of time, operative delivery is less effective for reducing the risk for neonatal infection. Intravenous acyclovir is the preferred drug and is administered pending definitive diagnosis. What is the relationship between age of acquisition of hepatitis B virus and the likelihood of chronic hepatitis B infection Neonates born to mothers with active hepatitis A infection are unlikely to contract the virus, and efficacy of postnatal prophylaxis with hepatitis A immunoglobulin has not been proved. The risk for vertical transmission of hepatitis C virus is about 5%, and no preventive therapy exists. Nucleic amplification testing can be done at 1 to 2 months of age, if desired, to assess for neonatal infection. Antibody testing cannot be done until after 18 months because that is the expected duration of the presence of passive maternal antibody in infants. Mothers with hepatitis C infection should be advised that transmission of hepatitis C by breastfeeding has not been documented. Accordingly, maternalhepatitisCinfectionisnotacontraindicationtobreastfeeding, although mothers with cracked or bleeding nipples should consider abstaining. The manifestations of congenital syphilis are protean and may be divided into early and late findings. Early manifestations occur during the first 2 years of life; late manifestations occur after 2 years of age (Table 11-3). Examples include the fluorescent treponemal antibody absorption test and the microhemagglutination test for T. Rarely seen in the United States, trachoma is an infection caused by certain serotypes of Chlamydia trachomatis. If untreated, a chronic follicular keratoconjunctivitis results in neovascularization and extensive scarring of the cornea. In children, the acute disease is generally mild and self-limited, whereas the chronic, scarring disease occurs more commonly in adults. Prevalence is more common in socioeconomically disadvantaged areas with crowding and inadequate water supplies. The World Health Organization estimates that about 6 million people are blind as a result of an untreated infection. A pregnant woman with a known chlamydial infection should be treated with oral erythromycin or azithromycin to reduce the risk for neonatal chlamydial pneumonia and conjunctivitis. Untreated mothers may transmit Chlamydia to babies born vaginally about 50% of the time. Simultaneous treatment of the male partners with doxycycline or azithromycin should also be undertaken. Should newborns of mothers with untreated chlamydial infection receive prophylactic antibiotic therapy Although these infants are at increased risk for infection, the efficacy of prophylactic antibiotics is not known, and treatment is not indicated. Infants should be followed carefully for signs of conjunctivitis or pneumonia and treatment initiated if indicated. If close follow-up cannot be ensured, some pediatric infectious disease experts would advise preemptive therapy. Assuming that the mother is untreated, first-trimester infection is associated with a fetal infection rate of about 25%, second-trimester infection with a rate of more than 50%, and third-trimester infection with a rate of roughly 65%. As with other congenital infections, the symptomatic neonatalpresentations are varied, rangingfrom severe disease withfever, hepatosplenomegaly, chorioretinitis, and/or neurologic features. Among asymptomatic infants, intracranial calcifications are often present, and long-term risks include impaired vision, learning disabilities, mental retardation, and seizures. How can a woman minimize the chance of acquiring a Toxoplasma infection during pregnancy Gonococci and some treponemes are killed at temperatures of 40 C (104 F) and higher, and benefits from fever therapy have been reported in cases of gonococcal urethritis and neurosyphilis. In addition, fever appears to hamper the growth of some types of pneumococci and some viruses. Fever is also associated with a decrease in the amount of free serum iron, which is an essential nutrient for many pathogenic bacteria. Modest fever can accelerate a variety of immunologic responses, including phagocytosis, leukocyte chemotaxis, lymphocyte transformation, and interferon production. On the other hand, other data indicate that high fever can impair the immune response. In addition, although the metabolic effects of fever are well tolerated by most children, in some situations, these effects can be dangerous. Examples include patients at risk for cardiac or respiratory failure and those with neurologic disease or with septic shock. Fever can precipitate febrile seizures in the susceptible population, which are children between 6 months and about 5 years of age. Especially in smaller children, fever can contribute to dehydration, increased sleepiness, and discomfort. Because body temperatures vary among individuals and age groups and vary over the course of the day in a given individual (lowest around 4:00 to 5:00 am and highest in late afternoon and early evening), a precise cutoff point is difficult to determine. In children between the ages of 2 and 6 years, diurnal variation can range up to 0. Infants tend to have a higher baseline temperature pattern, with 50% having daily rectal temperatures higher than 37. In addition, activity and exercise (within 30 minutes), feeding or meals (within 1 hour), and hot foods (within 1 hour) can cause body temperature elevations. Most authorities agree that, for a child younger than 3 months, a rectal temperature higher than 38 C (100. In those older than 2 years, as the baseline falls, fever more commonly is defined as a rectal temperature higher than 38 C (100. Ironically, these were axillary temperatures, and the waters of what constitutes normal have been muddied since. There can be significant variability in the relationship between different sites, and conversions should be done with caution. It is common for parents to report a subjective fever by palpation without measuring a temperature by thermometry. Palpation by parents has a sensitivity and specificity of about 80% in children older than 3 months. In infants younger than 3 months, the positive predictive value of a parent reporting a palpable fever is about 60%, with a negative-predictive value of 90%. For these younger infants, for whom identification of fever carries potentially greater clinical repercussions, parents seem to overestimate the presence of a fever, but they are more accurate when a child is afebrile. In infants who are younger than 3 months (when fever can be more significant clinically), a rectal temperature is the preferred method. Tympanic recordings are much less sensitive in this age group because the narrow, tortuous external canal can collapse, thereby resulting in readings obtained from the cooler canal rather than the warmer tympanic membrane. A foot as warm as the abdomen suggests an overly warm environment, whereas a foot that is cooler suggests fever with peripheral vasoconstriction. Long a doctrine of grandmothers, the suggested association between teething and temperature elevation may have some basis in fact. In one study of 46 healthy infants with rectal temperatures recorded for 20 days before the eruption of the first tooth, nearly half had a new temperature elevation of more than 37. Other studies have shown some statistical association with slight temperature increase. In any event, significantly elevated fever should not be ascribed simply to teething. Occult bacteremia refers to the finding of bacteria in the blood of patients, usually between the ages of 3 and 36 months, who are febrile without a clinically apparent focus of infection. This term should be distinguished from septicemia, which refers to the growth of bacteria in the blood of a child with the clinical picture of toxicity and shock. In trials done after the introduction of the Hib vaccine (1990) but before the introduction of the pneumococcal conjugate vaccine (2000), bacteremia rates for pneumococcus ranged from 1. Children who are incompletely immunized are at higher risk compared with the fully immunized. In the case of the conjugate pneumococcal vaccine, 7 vaccine serotypes and 2 cross-reactive serotypes composed the vaccine and accounted for about 80% of invasive pneumococcal disease. The overall incidence of invasive disease still remains well below the prevaccine level. This set of six items of observation and physical signs was designed at Yale to assist in detecting serious illness in febrile children who were younger than 24 months old. Normal (1 point), moderate impairment (3 points), and severe impairment (5 points) scores are given for quality of cry, reaction to parental stimulation, state of alertness, color, hydration, and response to social overtures. Scores of 10 or less correlate with a low likelihood of serious illness, primarily in infants older than 2 months. What is the proper way to evaluate and manage febrile illness in infants who are younger than 60 days This remains a contentious issue even in the era of the conjugate pneumococcal vaccine. On average, up to 10% of febrile infants who are younger than 2 months have serious bacterial infections (bacteremia, meningitis, osteomyelitis, septic arthritis, urinary tract infection, or pneumonia).

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Visek hiv infection rates new york city discount medex 5mg online, a renowned research scientist explained recently a link between excessive meat-eating and cancer hiv infection symptoms mouth order medex 1mg line. According to him xylometazolin antiviral order medex 5mg free shipping, the villain is ammonia hiv infection rates decreasing medex 5 mg overnight delivery, the carcinogenic by-product of meat digestion diferencia entre antiviral y vacuna generic medex 5mg on-line. Treatment the effective treatment of cancer consists of a complete change in diet antiviral wipes order medex 1 mg online, besides total elimination of all environmental sources of carcinogens, such as smoking and carcinogenic chemicals in air, water and food. There has recently been a surge of popular interest in the concept that diet is not just a minor, but rather a major factor in both the development and the prevention of cancer. As a first step, the patient should cleanse the system by thoroughly relieving constipation and making all the organs of elimination the skin, lungs, liver, kidneys and bowels active. For the first four or five days, the patient should take only juicy fruits like oranges, grapefruits, lemons, apples, peaches, pears, pineapples and tomatoes. After a few days of an exclusive fruit diet, the patient may be given a nourishing alkaline-based diet. It should consist of 100 per cent natural foods, with emphasis on raw fruits and vegetables. A minimum requirement of high quality protein, mostly from vegetable sources such as almonds, millet, sesame seeds, sprouted seeds and grains, may be added to the diet. Wigmore points out that by furnishing the body with live minerals, vitamins, trace elements and chlorophyll through wheatgrass juice, it may be able to repair itself. She discovered this mode of cure in 1925, while experimenting on herself by fasting and dieting alternately in the course of her nine-year battle with cancer. She recommends a fast for two or three days so as to prepare the system for the change of diet. After the short fast, the patient should have a grape meat every two hours from 8 a. This should be followed for a week or two even a month or two, in chronic cases of long standing. The patient should begin the grape cure with a small quantity of 30, 60, to 90 grams per meal, gradually increasing this to double the quantity. Recent researches have shown that certain vitamins can be successfully employed in the fight against cancer and that they can increase the life expectancy of some terminal cancer patients. According to recent Swedish studies vitamin C in large doses can be an effective prophylactic agent against cancer. Fukunir Morishige, and his colleagues who have been examining the healing potential of vitamin C for the last 30 years, have recently found that a mixture of vitamin C and copper compound has lethal effects on cancer. According to several studies, vitamin A exerts an inhibiting effect on carcinogenesis. Leonida Santamaria and his colleagues at the University of Pavia in Italy have uncovered preliminary evidence suggesting that beta-carotene, a precursor of vitamin A may actually inhibit skin cancer by helping the body thwart the cancer-causing process known as oxidation. Recent studies from all over the world suggest that a liberal use of green and yellow vegetables and fruits can prevent cancer. The 20-years old, ongoing Japanese study found that people who ate green and yellow vegetables every day had a decreased risk of developing lung, stomach and other cancers. A Harvard University study of more than 1, 200 elderly Massachusetts residents found that those who reported the highest consumption of carrots, squash, tomatoes, salads or leafy green vegetables, dried fruits, fresh strawberries or melon had a decreased risk of cancer. The other useful measures are plenty of rest, complete freedom from worries and mental stress and plenty of fresh, pure air. The term actually means a waterfall, and refers to the opacity of the crystalline lens of the eye on the assumption that the condition is caused by the humour of the brain falling over the pupil. The crystalline lens, through which light travels into the interior of the eye, is situated just behind the iris, or coloured portion of the eye. In cataract, this lens becomes opaque, hence seriously hampering the entrance of light into the eye. According to the modern medical system, a surgical operation to remove the lens or a major portion of it is the only way to get rid of the disease. The patient is provided with suitable glasses after the operation to enable him to see well enough to carry on his normal duties. At first, vision in twilight may be better than in full daylight since light is admitted round the more widely-dilated pupil in the dark. These are stagnation of the fluid current in the lens resulting from blood condition; deterioration in the nutrition of the lens which diminishes the vitality and resistence of the delicate lens fibres; deposits between the lens fibres of acids and salts which have an irritating effect on the lens tissues and exert an increasing pressure on its delicate fibres, clouding whole lens in the absence of appropriate measures. As in the case of most diseases, poisons in the blood stream due to dietetic errors and a faulty style of living is the real cause of cataract. The toxic matter in the blood stream spreads throughout the body to find shelter in any available weak spot. It strikes the lens if that part has become weak through strain, excessive use of the eyes and local irritation. The condition becomes worse with the passage of time and then a cataract starts developing. Other causes of cataract are stress and strain, excessive intake of alcoholic drinks, sugar, salt, smoking, certain physical ailments such as gastro-intestinal or gall bladder disturbance, diabetes, vitamin deficiencies, especially of vitamin C, fatty acid intolerance, ageing, radiation and side effects of drugs prescribed for other diseases. Some specialists believe that the most important cause of many cataract is poor nutrition. This may be true even in case of the type of cataract commonly called senile or ageing cataract. Morgan Raiford, an opthalmologist who has studied cataracts for many years, considers faulty nutrition to be a basic factor in cataract. He has found from experience that prevention of cataract is initiated by improving nutrition. Treatment Cataract is one of the most stubborn conditions to deal with, if it has become deep-seated, nothing short of a surgical operation will help in overcoming the trouble. If, however, the cataract is in the early stages, there are good chances of getting over the ailment by natural means. To start with, it will be beneficial to undergo a fast for three to four days on orange juice and water. In this regimen, breakfast may consist of oranges or grapes or any other juicy fruit in season. Raw vegetable salads in season, with olive oil and lemon juice dressing, and soaked raisins, figs or dates should be taken during lunch. Evening meals may consist of vegetable such as spinach, fenugreek, drum sticks, cabbage, cauliflower, carrot, turnips, steamed in their own juices, and a few nuts or some fruits, such as apples, pears and grapes. After two weeks on this diet, the cataract patient may start on a fuller diet on the following lines: Breakfast: Any fresh fruits in season, except bananas. Lunch: A large mixed raw vegetable salad with wholemeal bread or chapatis and butter. The short fast followed by a restricted diet should be repeated after three months of the commencement of the treatment and again three months later, if necessary. The bowels should be cleansed daily with a warm water enema during the fast, and afterwards as necessary. The patient should avoid white bread, sugar, cream, refined cereals, rice, boiled potatoes, puddings and pies, strong tea or coffee, alcoholic beverages, condiments, pickles, sauces or other so-called aids to digestion. There is increasing evidence to show that in several cases cataracts have actually been reversed by proper nutritional treatment. However, the time needed for such treatment may extend from six months to three years. She states that the diet of the cataract patient should be high in B2, B6, as well as whole B-complex, panto thenic acid, vitamin C, D, E and other nutrients. The patient should take about six grams of aniseed daily in the morning and evening. Equal weights of aniseed and coriander powder and mixed with brown sugar is also beneficial in the treatment of this disease and the mixture should be taken in doses of 12 grams in the morning and evening. Another valuable remedy for cataract is to grind seven kernels of almonds and half a gram of pepper together in water, and then drink the mixture after sifting and sweetening the mixture with sugar candy. Simultaneous with the dietary treatment, the patient should adopt various methods of relaxing and strengthening the eyes. These include moving the eyes gently up and down, from side to side and in a circle, clock-wise and anti-clockwise; rotating the neck in circles and semi-circles and briskly moving the shoulders clock-wise and anti-clockwise. The patient should also resort to palming which is highly beneficial in removing strain and relaxing the eyes and its surrounding tissues. The patient should remain in the bath from 25 to 35 minutes till he perspires freely. Closed eyes should also be bathed at least twice daily with hot water containing epsom salt a tablespoonful of salt to a large cupful of hot water. In cases where the cataract has been caused by stress, an antistress diet rich in protein, vitamin B, C, E, pantothenic acid and nutrients is essential to overcome the trouble. If a cataract has already developed, the diet will help prevent its occurrence in the other type. Fresh air and gentle outdoor exercises, such as walking, are other essentials to the treatment. It produces bile, cholesterol, lecithin, blood albumin vital to the removal of tissue wastes prothrombin essential to the clotting of blood and numerous enzymes. It inactivates hormones no longer needed, synthesises many amino acids used in building tissues and breaks proteins into sugar and fat when required for energy. It also destroys harmful substances and detoxifies drugs, poisons, chemicals and toxins from bacterial infections. In cirrhosis of the liver, although regenerative activity continues, the progressive loss of liver cells exceeds cell replace ment. There is also progressive distortion of the vascular system which interferes with the portal blood flow through the liver. The progressive degeneration of liver structure and function may ultimately lead to hepatic failure and death. Symptoms In the early stages of the diseases, there may be nothing more than frequent attacks of gas and indigestion, with occasional nausea and vomiting. Reddish hair like markings, resembling small spiders, may appear on the face, neck, arms and trunk. The abdomen becomes bloated and swollen, the mind gets clouded and there may be considerable bleeding from the stomach. Causes Excessive use of alcohol over a long period is the most potent cause of cirrhosis of the liver. It has been estimated that one out of 12 chronic alcoholics in the United States develops cirrhosis. The disease can progress to end-stage of hepatic failure if the person does not abstain from alcohol. Cirrhosis appears to be related to the duration of alcohol intake and the quantity consumed daily. Recent researches indicate that the average duration of alcohol intake to produce cirrhosis is 10 years and the dose is estimated to be in excess of 500 ml of alcohol daily. Poor nutrition can be another causative factor in the development of cirrhosis and a chronic alcoholic usually suffers from severe malnutrition as he seldom eats. Other causes of cirrhosis are excessive intake of highly seasoned food, habitual taking of quinine for a prolonged period in tropical climate, and drug treatments for syphillis, fever and other diseases. In fact, anything which continually overburdens the liver cells and leads to their final breakdown can be a contributing cause of cirrhosis. He should undergo an initial liver cleaning programme with a juice fast for seven days. Freshly extracted juices from red beets, lemon, papaya and grapes may be taken during this period. In this regimen, the patient should have three meals a day, each of fresh juicy fruits and milk. The fruits may include apples, pears, grapes, grape fruit, oranges, pineapples and peaches. After the fruit and milk diet, the patient may gradually embark upon a well-balanced diet of three basic food groups, namely (i) seeds, nuts and grains, (ii) vegetables and (iii) fruits, with emphasis on raw organically grown foods. Vegetables such as beets, squashes, bitter gourd, egg-plant, tomato, carrot, radishes and papaya are useful in this condition. The patient should avoid all refined, processed and canned foods, sugar in any form, spices and condiments, strong tea and coffee, fried foods, all preparations cooked in ghee, oil or butter and all meats rich in fat. The patient should also avoid all chemical additives in food and poisons in air, water and environment. Application of alternate compress to liver area followed by general wet sheet rub will be beneficial. The morning dry friction and breathing and other exercises should form a regular daily feature of the treatment. Mucus colitis is a common disorder of the large bowel, producing discomfort and irregular bowel habits.

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